- PKR
- OAS1
- OAS2
- OAS3
- RIG-I
- MDA5
- TLR3
- TLR7
- TLR8
- TLR9
- NLRP3
- NOD2
- AIM2
- ZBP1
| Sensor symbol | PKR |
|---|---|
| Gene name | eukaryotic translation initiation factor 2-alpha kinase 2 |
| Protein name | Interferon-induced, double-stranded RNA-activated protein kinase |
| Aliases | EIF2AK2, EIF2AK1, PRKR |
| HGNC ID | 9437 |
| Gene | 5610 |
| OMIM ID | 176871 |
| Transcript | NM_002759.3 NM_001135651.2 NM_001135652.2 |
| Gene expression | BioGPS |
| Protein | UniProt NP_001129123.1 NP_001129124.1 NP_002750.1 |
| Localization | cytoplasm, nucleus |
| Ligand | dsRNA, 5-prime-triphosphate RNA |
| Adaptor protein | eIF2a, NFkB, ATF2, p38 |
| Pathway | BIOCARTA |
| References | PubMed |
| Sensor symbol | OAS1 |
|---|---|
| Gene name | 2',5'-oligoadenylate synthetase 1, 40/46kDa |
| Protein name | 2'-5'-oligoadenylate synthase 1 |
| Aliases | OIAS, OIASI, IFI-4 |
| HGNC ID | 8086 |
| Gene | 4938 |
| OMIM ID | 164350 |
| Transcript | NM_001032409.1 NM_002534.2 NM_016816.2 |
| Gene expression | BioGPS |
| Protein | UniProt NP_001027581.1 NP_002525.2 NP_058132.2 |
| Localization | Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions |
| Ligand | dsRNA |
| Adaptor protein | RNaseL |
| Pathway | RNAimmuno |
| References | PubMed |
| Sensor symbol | OAS2 |
|---|---|
| Gene name | 2'-5'-oligoadenylate synthetase 2, 69/71kDa |
| Protein name | 2'-5'-oligoadenylate synthase 2 |
| Aliases | - |
| HGNC ID | 8087 |
| Gene | 4939 |
| OMIM ID | 603350 |
| Transcript | NM_001032731.1 NM_002535.2 NM_016817.2 |
| Gene expression | BioGPS |
| Protein | UniProt NP_001027903.1 NP_002526.2 NP_058197.2 |
| Localization | Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions |
| Ligand | dsRNA |
| Adaptor protein | RNaseL |
| Pathway | RNAimmuno |
| References | PubMed |
| Sensor symbol | OAS3 |
|---|---|
| Gene name | 2',5'-oligoadenylate synthetase 3, 100 kD |
| Protein name | 2'-5'-oligoadenylate synthase 3 |
| Aliases | - |
| HGNC ID | 8088 |
| Gene | 4940 |
| OMIM ID | 603351 |
| Transcript | NM_006187.2 |
| Gene expression | BioGPS |
| Protein | UniProt NP_006178.2 |
| Localization | Associated with microsomal fractions |
| Ligand | dsRNA |
| Adaptor protein | RNaseL |
| Pathway | RNAimmuno |
| References | PubMed |
| Sensor symbol | DDX58 |
|---|---|
| Gene name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| Protein name | Probable ATP-dependent RNA helicase DDX58 |
| Aliases | RIG-I, FLJ13599, DKFZp434J1111 |
| HGNC ID | 19102 |
| Gene | 23586 |
| OMIM ID | 609631 |
| Transcript | NM_014314.3 |
| Gene expression | BioGPS |
| Protein | UniProt NP_055129.2 |
| Localization | cytoplasm |
| Ligand | blunt-ended dsRNA, 5-prime-triphosphate RNA |
| Adaptor protein | IPS-1 |
| Pathway |
KEGG_1 KEGG_2 InvivoGen |
| References | PubMed |
| Sensor symbol | IFIH1 |
|---|---|
| Gene name | interferon induced with helicase C domain 1 |
| Protein name | Interferon-induced helicase C domain-containing protein 1 |
| Aliases | MDA-5, Hlcd, MDA5, IDDM19 |
| HGNC ID | 18873 |
| Gene | 64135 |
| OMIM ID | 606951 |
| Transcript | NM_022168.3 |
| Gene expression | BioGPS |
| Protein | UniProt NP_071451.2 |
| Localization | Cytoplasm, may be found in the nucleus, during apoptosis |
| Ligand | Long dsRNA |
| Adaptor protein | MAVS/IPS1 |
| Pathway |
KEGG InvivoGen |
| References | PubMed |
| Sensor symbol | TLR3 |
|---|---|
| Gene name | Toll-like receptor |
| Protein name | Toll-like receptor 3 |
| Aliases | CD283 |
| HGNC ID | 11849 |
| Gene | 7098 |
| OMIM ID | 603029 |
| Transcript | NM_003265.2 |
| Gene expression | BioGPS |
| Protein | UniProt NP_003256.1 |
| Localization | Endoplasmic reticulum membrane, endosome membrane, cell membrane |
| Ligand | dsRNA |
| Adaptor protein | TRIF |
| Pathway |
KEGG BIOCARTA InvivoGen PRRDB |
| References | PubMed |
| Sensor symbol | TLR7 |
|---|---|
| Gene name | Toll-like receptor 7 |
| Protein name | Toll-like receptor 7 |
| Aliases | - |
| HGNC ID | 15631 |
| Gene | 51284 |
| OMIM ID | 300365 |
| Transcript | NM_016562 |
| Gene expression | BioGPS |
| Protein | UniProt NP_057646.1 |
| Localization | Plasma membrane, endosome membrane |
| Ligand | ssRNA |
| Adaptor protein | MyD88 |
| Pathway |
KEGG BIOCARTA InvivoGen PRRDB |
| References | PubMed |
| Sensor symbol | TLR8 |
|---|---|
| Gene name | Toll-like receptor 8 |
| Protein name | Toll-like receptor 8 |
| Aliases | CD288 |
| HGNC ID | 15632 |
| Gene | 51311 |
| OMIM ID | 300366 |
| Transcript | NM_138636.4 |
| Gene expression | BioGPS |
| Protein | UniProt NP_619542.1 |
| Localization | Plasma membrane, endosome membrane |
| Ligand | ssRNA |
| Adaptor protein | MyD88 |
| Pathway |
KEGG BIOCARTA InvivoGen PRRDB |
| References | PubMed |
| Sensor symbol | TLR9 |
|---|---|
| Gene name | Toll-like receptor 9 |
| Protein name | Toll-like receptor 9 |
| Aliases | CD289 |
| HGNC ID | 15633 |
| Gene | 54106 |
| OMIM ID | 605474 |
| Transcript | NM_017442.3 |
| Gene expression | BioGPS |
| Protein | UniProt NP_059138.1 |
| Localization | Plasma membrane, endosome membrane |
| Ligand | CpG DNA |
| Adaptor protein | MyD88 |
| Pathway |
KEGG BIOCARTA InvivoGen PRRDB |
| References | PubMed |
| Sensor symbol | NLRP3 |
|---|---|
| Gene name | NLR family, pyrin domain containing 3 |
| Protein name | NACHT, LRR and PYD domains-containing protein 3 |
| Aliases | AGTAVPRL, AII, AVP, FCAS, FCU, NALP3, PYPAF1, MWS, CLR1.1, C1orf7, CIAS1 |
| HGNC ID | 16400 |
| Gene | 114548 |
| OMIM ID | 606416 |
| Transcript | NM_001079821.2 NM_001127461.2 NM_001127462.2 NM_004895.4 NM_183395.2 |
| Gene expression | BioGPS |
| Protein |
UniProt NP_001120933.1 NP_001120934.1 NP_004886.3 NP_899632.1 |
| Localization | cytoplasm |
| Ligand | RNA |
| Adaptor protein | ASC |
| Pathway | KEGG |
| References | PubMed |
| Sensor symbol | NOD2 |
|---|---|
| Gene name | nucleotide-binding oligomerization domain containing 2 |
| Protein name | nucleotide-binding oligomerization domain-containing protein 2, caspase recruitment domain-containing protein 15 |
| Aliases | BLAU, CD, PSORAS1, CLR16.3, NLRC2, CARD15, IBD1 |
| HGNC ID | 5331 |
| Gene | 64127 |
| OMIM ID | 605956 |
| Transcript | NM_022162.1 |
| Gene expression | BioGPS |
| Protein |
UniProt NP_071445 |
| Localization | cytoplasm |
| Ligand | ssRNA |
| Adaptor protein | IPS-1 |
| Pathway |
KEGG RNAimmuno |
| References | PubMed PubMed |
| Sensor symbol | AIM2 |
|---|---|
| Gene name | Absent in melanoma 2 |
| Protein name | Interferon-inducible protein AIM2, Absent in melanoma 2 |
| Aliases | PYHIN4 |
| HGNC ID | 357 |
| Gene | 9447 |
| OMIM ID | 604578 |
| Transcript | NM_004833.1 |
| Gene expression | BioGPS |
| Protein | UniProt NP_004824.1 |
| Localization | Cytoplasm, nucleus |
| Ligand | DNA |
| Adaptor protein | ASC-CASP1 |
| Pathway | KEGG |
| References | PubMed |
| Sensor symbol | ZBP1 |
|---|---|
| Gene name | Z-DNA binding protein 1 |
| Protein name | Z-DNA-binding protein 1, DNA-dependent activator of IRFs |
| Aliases | DAI, C20orf183, dJ718J7.3, DLM1, DLM-1 |
| HGNC ID | 16176 |
| Gene | 81030 |
| OMIM ID | 606750 |
| Transcript | NM_030776.2 NM_001160417.1 NM_001160418.1 NM_001160419.1 |
| Gene expression | BioGPS |
| Protein | UniProt NP_110403.2 NP_001153889.1 NP_001153890.1 NP_001153891.1 |
| Localization | cytoplasm |
| Ligand | DNA |
| Adaptor protein | - |
| Pathway | KEGG |
| References | PubMed |